The Research Progress of SQUID Magnetoneurography at SIMIT
2025-06-18 , Room "Berlin & Oslo"

Magnetoneurography (MNG) [1] is a new SQUID biomagnetic detection method to measure human nerve current flow [2], which has high clinical application value in the diagnosis of neurological diseases [3], [4]. Since the strength of the MNG signal is about several tens of fT, and the signal frequency band is in the hundreds of Hz [5] , it is mainly detected by SQUID, and it is difficult to effectively measure MNG by other detectors such as Optically Pumped Magnetometers (OPMs) until now. In recent years, a prototype has been developed in Japan and MNG detection based on patch electrode stimulation has been carried out[6]. At present, we have built a SQUID MNG system, which achieves the frequency-domain noise level of about 2.8 fT/sqrt(Hz) and the time-domain noise level of about 24 fT. Based on the system, we carried out SQUID MNG measurement and detected MNG signal with intensity of about 100 fT. MNG imaging was realized and the nerve conduction wave velocity of about 50 m/s was detected. In addition, we have also cooperated with the hospital to carry out research work on MNG detection combined with traditional Chinese medicine acupuncture methods, which will help in the diagnosis and treatment of nerve conduction diseases.


Affiliation:

Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences (CAS)

Additional Authors with Affiliation:

Shulin Zhang, Guofeng Zhang, Yongliang Wang, Limin Sun, and Xiaoming Xie